Our research spans the spectrum from benchtop food chemistry and botanical extraction to computational simulations and in-vivo genetic assays. What unites our work is an insistence on rigorous empirical methodology, reproducible protocols, and research questions directly relevant to nutrition, public health, and biotechnology in Bangladesh.
Each theme is led by specialized methodologies and dedicated laboratory equipment.
Isolation, characterization, and quantification of bioactive secondary metabolites from native Bangladeshi fruits, wild palms, vegetables, and coastal macroalgae (such as Ulva lactuca). We focus on identifying functional components with potential health-promoting and disease-preventive applications.
Qualitative and quantitative characterization of total phenolics, total flavonoids, reducing power, and free-radical scavenging capacity across varying solvent polarities using biochemical and spectrophotometric assays.
Computer-aided drug design (CADD), molecular docking, network pharmacology, target prediction, and in-silico ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling to elucidate molecular mechanisms of candidate natural compounds.
Investigation of gene expression modulation, cellular stress responses, and metabolic pathways affected by dietary nutraceuticals, with applications in diabetes, neurodegeneration, and inflammatory models.
Culturing and molecular characterization of symbiotic gut bacterial flora in phytophagous insects (grasshoppers, defoliating beetles) to isolate high-efficiency cellulases, xylanases, and endoglucanases for industrial and bioenergy applications.
Using Caenorhabditis elegans as a transparent, genetically tractable multicellular model organism to evaluate oxidative stress tolerance, longevity extension, motility, and in-vivo safety of natural plant extracts.
Caenorhabditis elegans serves as an internationally recognized model organism sharing ~60–80% gene homology with human disease pathways. At our Chittagong facility, we maintain synchronized nematode cultures on NGM plates seeded with E. coli OP50 to test bioactive extracts in living systems.
Overview of active funded investigations, pandemic readiness initiatives, and completed biotechnology programs in our laboratory.
Comparative profiling and quantification of bioactive secondary metabolites, polyphenols, lipids, carotenoids, and proximate nutritional quality across red (Rhodophyta), green (Chlorophyta), and brown (Phaeophyceae) macroalgae native to coastal Bangladesh.
Strategic multi-year institutional investigation focusing on molecular etiology of infectious pathogens, assessing clinical therapeutics in practice, and engineering novel candidate antiviral formulations and translational intervention strategies.
Developing an eco-friendly elicitation strategy using enzyme-free metal ion synergies in lieu of live fungal inoculants (Fusarium spp.) to accelerate oleoresin synthesis and substantially shorten agarwood resin induction time.
Quantitative evaluation of proximate nutritional constituents, total phenolic and flavonoid contents, DPPH/FRAP radical scavenging capabilities, and storage stability in commercially farmed seaweeds across the Bay of Bengal coastline.
Biochemical profiling and antioxidant evaluation comparing indigenous wild date palm fruits (Phoenix sylvestris) with imported exotic varieties (Phoenix dactylifera), assessing carbohydrates, amino acids, minerals, and polyphenols.
In-vitro phytochemical and antioxidant assessment of diverse native Curcuma rhizome extracts coupled with in-vivo lifespan longevity assays, locomotion preservation, and heat/oxidative stress resistance assays in synchronized Caenorhabditis elegans.
Culture-dependent isolation, biochemical screening, and 16S rRNA gene sequencing of endosymbiotic cellulolytic bacteria residing in phytophagous insect digestive tracts, evaluating their catalytic capacity for lignocellulosic biomass bioconversion into fermentable sugars.
Biodiversity screening of indigenous defoliating beetles, grasshoppers, and phytophagous larvae across Bangladesh to quantify crude endoglucanase, exoglucanase, and β-glucosidase titers and optimize biochemical reaction kinetics for biofuel production.
From indigenous botanical collection to target validation and in-vivo physiological outcomes.
